Preheat your oven to 350°F (175°C). Grease and flour a loaf pan.
In a medium bowl, whisk together flour, baking powder, baking soda, and salt.
In a large bowl, cream the butter and sugar until light and fluffy. Beat in eggs, one at a time.
Stir in the lemon zest, lemon juice, and vanilla extract.
Gradually mix in the dry ingredients alternately with buttermilk, starting and ending with dry ingredients.
Pour the batter into the prepared pan and bake for 45-50 minutes or until a toothpick inserted into the center comes out clean.
Let the cake cool in the pan for 10 minutes, then transfer to a wire rack to cool completely.
For the glaze:
In a small bowl, combine the powdered sugar, lemon juice, and lemon zest until smooth.
Drizzle the glaze over the cooled cake. Allow it to set before slicing.
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